Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy.

@article{Kim2013TriheptanoinRS,
  title={Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy.},
  author={Tae Hwan Kim and Karin Borges and Steven Petrou and Christopher A. Reid},
  journal={Epilepsy research},
  year={2013},
  volume={103 1},
  pages={101-5}
}
Triheptanoin is a triglyceride containing heptanoate, an odd-chained medium fatty acid that is metabolized to produce propionyl-CoA and subsequently C4 intermediates of the citric acid cycle and therefore capable of anaplerosis. These metabolic products are believed to underlie triheptanoin's anticonvulsant effects in rodent seizure models. Here we… CONTINUE READING