Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans

@article{Chandak2006TriglycerideAP,
  title={Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans},
  author={Giriraj Ratan Chandak and Kirsten J Ward and Chittaranjan Yajnik and Anand Neelkanth Pandit and Ashish R Bavdekar and Charu V Joglekar and Caroline H. D. Fall and P. Mohankrishna and Terence J. Wilkin and Bradley S Metcalf and M. N. Weedon and Timothy M. Frayling and Andrew T Hattersley},
  journal={BMC Medical Genetics},
  year={2006},
  volume={7},
  pages={76 - 76}
}
The APOA5 gene variants, -1131T>C and S19W, are associated with altered triglyceride concentrations in studies of subjects of Caucasian and East Asian descent. There are few studies of these variants in South Asians. We investigated whether the two APOA5 variants also show similar association with various lipid parameters in Indian population as in the UK white subjects. We genotyped 557 Indian adults from Pune, India, and 237 UK white adults for -1131T>C and S19W variants in the APOA5 gene… CONTINUE READING