Triglyceride accumulation protects against fatty acid-induced lipotoxicity.

  title={Triglyceride accumulation protects against fatty acid-induced lipotoxicity.},
  author={Laura L. Listenberger and Xianlin Han and Sarah E Lewis and Sylvaine Cases and Robert V Farese and Daniel S Ory and Jean E Schaffer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 6},
Excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic beta-cell apoptosis and heart failure. Here, we demonstrate in cultured cells that the relative toxicity of two common dietary long chain fatty acids is related to channeling of these lipids to distinct cellular metabolic fates. Oleic acid supplementation leads to triglyceride accumulation and is well tolerated, whereas excess palmitic acid is poorly incorporated into triglyceride and causes… CONTINUE READING
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