Triggers and switches in a self-assembling pore-forming protein.

  title={Triggers and switches in a self-assembling pore-forming protein.},
  author={Hagan Bayley},
  journal={Journal of cellular biochemistry},
  volume={56 2},
  • Hagan Bayley
  • Published 1994 in Journal of cellular biochemistry
Protein engineering is being used to produce a collection of pore-forming proteins with applications in biotechnology. Knowledge provided by investigations of the mechanism of self-assembly of staphylococcal alpha-hemolysin has allowed the design of genetically and chemically modified variants of the protein with pore-forming activities that can be triggered or switched on-and-off by chemical, biochemical and physical inputs. Examples include alpha-hemolysins that are activated by specific… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…