Triggering unfolded protein response by 2-Deoxy-D-glucose inhibits porcine epidemic diarrhea virus propagation.

@article{Wang2014TriggeringUP,
  title={Triggering unfolded protein response by 2-Deoxy-D-glucose inhibits porcine epidemic diarrhea virus propagation.},
  author={Yue Wang and Jia-rong Li and Ming-xia Sun and Bo Ni and Changchao Huan and Li Huang and Chen Li and Hongjie Fan and Xue-Ping. Ren and Xiang Mao},
  journal={Antiviral research},
  year={2014},
  volume={106},
  pages={33-41}
}
The unfolded protein response (UPR) is cyto-protective machinery elicited towards an influx of large amount of protein synthesis in the endoplasmic reticulum (ER). Extensive studies suggest that the UPR can also be activated during virus infection. In the present studies, we first evaluated if porcine epidemic diarrhea virus (PEDV) infection activated the UPR pathways. Electron microscopy analysis demonstrated the morphology changes of ER post-PEDV infection. Western blot and real-time PCR… CONTINUE READING