Triggering the interferon antiviral response through an IKK-related pathway.

  title={Triggering the interferon antiviral response through an IKK-related pathway.},
  author={Sonia P Sharma and Benjamin R tenOever and Nathalie Grandvaux and Guo-Ping Zhou and Rongtuan Lin and John Hiscott},
  volume={300 5622},
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK… CONTINUE READING
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