Triggering the induction of myofibroblast and fibrogenesis by airway epithelial shedding.

@article{Morishima2001TriggeringTI,
  title={Triggering the induction of myofibroblast and fibrogenesis by airway epithelial shedding.},
  author={Yasuo Morishima and Akihiro Dainippon Scree Nomura and Yoshiyuki Uchida and Yutaka Noguchi and Tohru Sakamoto and Yukio Ishii and Yoshinobu Goto and Keisuke Masuyama and Ming Zhang and Kiyomi Hirano and Michika Mochizuki and Morio Ohtsuka and Kiyohisa Sekizawa},
  journal={American journal of respiratory cell and molecular biology},
  year={2001},
  volume={24 1},
  pages={
          1-11
        }
}
Myofibroblasts have been thought to participate in subepithelial fibrosis in asthma, but the mechanism of myofibroblast induction has not been fully understood. In this study we investigated injury-related myofibroblast induction in a coculture system of guinea-pig epithelial cells and fibroblasts cocultured in a human amnion chamber. After pseudostratified epithelial cells were mechanically scraped, migrated flat epithelial cells differentiated into cuboidal appearances on Day 4 and then… CONTINUE READING
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