Triggering the Resolution of Immune Mediated Inflammatory Diseases: Can Targeting Leukocyte Migration Be the Answer?

@inproceedings{Hopkin2019TriggeringTR,
  title={Triggering the Resolution of Immune Mediated Inflammatory Diseases: Can Targeting Leukocyte Migration Be the Answer?},
  author={Sophie J. Hopkin and Jonathan W. Lewis and Franziska Krautter and Myriam Chimen and Helen M McGettrick},
  booktitle={Front. Pharmacol.},
  year={2019}
}
Leukocyte recruitment is a pivotal process in the regulation and resolution of an inflammatory episode. It is vital for the protective responses to microbial infection and tissue damage, but is the unwanted reaction contributing to pathology in many immune mediated inflammatory diseases (IMIDs). Indeed, it is now recognized that patients with IMIDs have defects in at least one, if not multiple, check-points regulating the entry and exit of leukocytes from the inflamed site. In this review, we… CONTINUE READING
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