Triggering sporulation in Bacillus subtilis with artificial two-component systems reveals the importance of proper Spo0A activation dynamics.

@article{Vishnoi2013TriggeringSI,
  title={Triggering sporulation in Bacillus subtilis with artificial two-component systems reveals the importance of proper Spo0A activation dynamics.},
  author={Monika Vishnoi and Jatin Narula and Seram Nganbiton Devi and Hoang-Anh Dao and Oleg A. Igoshin and Masaya Fujita},
  journal={Molecular microbiology},
  year={2013},
  volume={90 1},
  pages={181-94}
}
Sporulation initiation in Bacillus subtilis is controlled by the phosphorylated form of the master regulator Spo0A which controls transcription of a multitude of sporulation genes. In this study, we investigated the importance of temporal dynamics of phosphorylated Spo0A (Spo0A∼P) accumulation by rewiring the network controlling its phosphorylation. We showed that simultaneous induction of KinC, a kinase that can directly phosphorylate Spo0A, and Spo0A itself from separately controlled… CONTINUE READING

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