Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals

@article{Yu2014TriggeringRE,
  title={Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals},
  author={Jin-Tai Yu and Teng Jiang and Ying-li Wang and Hui-fu Wang and Lan Tan},
  journal={Neurobiology of Aging},
  year={2014},
  volume={35},
  pages={937.e1-937.e3}
}
Recent studies have reported that a rare mutation of triggering receptor expressed on myeloid cells 2 gene (TREM2 [rs75932628-T]) has significantly increased the risk of late-onset Alzhemier's disease (LOAD) in European-descendent population. To date, no study has investigated the association between rare mutations of TREM2 and LOAD risk in non-European population. Here, we sequenced exon2 of TREM2 in the northern Han Chinese population consisting of 1133 patients with LOAD and 1159 control… CONTINUE READING
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