Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival.

@article{Radsak2004TriggeringRE,
  title={Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival.},
  author={Markus Philipp Radsak and Helmut Rainer Salih and Hans-Georg Rammensee and Hansjoerg Schild},
  journal={Journal of immunology},
  year={2004},
  volume={172 8},
  pages={
          4956-63
        }
}
Polymorphonuclear neutrophils (PMN) are crucial in the innate host defense by their ability to rapidly accumulate in inflamed tissues and clear a site of infection from microbial pathogens by their potent effector mechanisms. The triggering receptor expressed on myeloid cells (TREM)-1 is a recently described activating receptor on PMN with an important role in inflammation. However, the effects of TREM-1 stimulation on a cellular level remain to be further defined. To characterize TREM-1… CONTINUE READING
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