Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors.

@article{Netea2006TriggeringRE,
  title={Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors.},
  author={Mihai G Netea and Tania Azam and Gerben Ferwerda and Stephen E. Girardin and Soo-Hyun Kim and Charles A Dinarello},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={80 6},
  pages={1454-61}
}
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of a new family of myeloid receptors, encoded by a gene cluster linked to the MHC. Engagement of TREM-1 stimulates intracellular signals, resulting in activation of phagocytosis, neutrophil degranulation, and amplification of cytokine production induced by TLRs. In the present study, a novel property following engagement of TREM-1 is described, namely the amplification of cytokine production induced by the second major class… CONTINUE READING