Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance.

  title={Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance.},
  author={Julien Cherfils-Vicini and Sophia Platonova and M{\'e}lanie Gillard and Ludivine Laurans and Pierre Validire and Rafaele Caliandro and Pierre Magdeleinat and Fathia Mami-Chouaib and Marie-Caroline Dieu-Nosjean and Wolf-Herman Fridman and Diane Damotte and Catherine Saut{\`e}s-Fridman and Isabelle Cremer},
  journal={The Journal of clinical investigation},
  volume={120 4},
Compelling evidence suggests that inflammation, cell survival, and cancer are linked, with a central role played by NF-kappaB. Recent studies implicate some TLRs in tumor development based on their ability to facilitate tumor growth; however, to our knowledge, involvement of neither TLR7 nor TLR78 has yet been demonstrated. Here we have demonstrated expression of TLR7 and TLR8, the natural receptors for single-stranded RNA, by tumor cells in human lung cancer in situ and in human lung tumor… CONTINUE READING


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