Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.

@article{Valzasina2005TriggeringOO,
  title={Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.},
  author={Barbara Valzasina and Cristiana Guiducci and Heidrun Dislich and Nigel Killeen and Andrew D. Weinberg and Mario P Colombo},
  journal={Blood},
  year={2005},
  volume={105 7},
  pages={2845-51}
}
OX40 (CD134) is a member of the tumor necrosis factor (TNF) receptor family that is transiently expressed on T cells after T-cell receptor (TCR) ligation. Both naive and activated CD4(+)CD25+ regulatory T cells (T reg's) express OX40 but its functional role has not been determined. Since glucocorticoid-induced tumor necrosis factor receptor (GITR), a related TNF receptor family member, influences T reg function, we tested whether OX40 might have similar effect. Triggering either GITR or OX40 on… CONTINUE READING
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