Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma

  title={Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma},
  author={Katelyn E. McCabe and Karl Bacos and D Lu and Joe Ryan Delaney and Josh Axelrod and Matthew D. Potter and Mitchell Vamos and Venus W. Wong and Nicholas D. P. Cosford and R Xiang and Dwayne G. Stupack},
  booktitle={Cell Death and Disease},
Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the ‘inhibitor of apoptosis proteins’ (IAPs), also called SMAC mimetics, as apoptosis-inducing agents whose action is opposed by caspase inhibitors. Surprisingly, IAP antagonist plus caspase inhibitor (IZ) treatment selectively induced a tumor necrosis… CONTINUE READING
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