Triggering and amplifying pathways of regulation of insulin secretion by glucose.

@article{Henquin2000TriggeringAA,
  title={Triggering and amplifying pathways of regulation of insulin secretion by glucose.},
  author={Jean-Claude Henquin},
  journal={Diabetes},
  year={2000},
  volume={49 11},
  pages={1751-60}
}
Glucose stimulates insulin secretion by generating triggering and amplifying signals in beta-cells. The triggering pathway is well characterized. It involves the following sequence of events: entry of glucose by facilitated diffusion, metabolism of glucose by oxidative glycolysis, rise in the ATP-to-ADP ratio, closure of ATP-sensitive K+ (KATP) channels, membrane depolarization, opening of voltage-operated Ca2+ channels, Ca2+ influx, rise in cytoplasmic free Ca2+ concentration ([Ca2+]i), and… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS