Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1.

@article{Zaarur2008TriggeringAF,
  title={Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1.},
  author={Nava Zaarur and Anatoli B Meriin and Vladimir L. Gabai and Michael Yu Sherman},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 41},
  pages={27575-84}
}
Abnormal polypeptides that escape proteasome-dependent degradation and aggregate in cytosol can be transported via microtubules to an aggresome, a recently discovered organelle where aggregated proteins are stored or degraded by autophagy. We used synphilin 1, a protein implicated in Parkinson disease, as a model to study mechanisms of aggresome formation. When expressed in naïve HEK293 cells, synphilin 1 forms multiple small highly mobile aggregates. However, proteasome or Hsp90 inhibition… CONTINUE READING