Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis

@article{Huang2012TriggeringFP,
  title={Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis},
  author={Huilin Huang and H. Weng and Lu-Qin Wang and Chun-Hong Yu and Qiaojuan Huang and Pan-pan Zhao and J. Wen and H. Zhou and L. Qu},
  journal={Molecular Cancer Therapeutics},
  year={2012},
  volume={11},
  pages={1155 - 1165}
}
The transcription factor c-Myc is important in cell fate decisions and is frequently overexpressed in cancer cells, making it an attractive therapeutic target. Natural compounds are among the current strategies aimed at targeting c-Myc, but their modes of action still need to be characterized. To explore the mechanisms underlying the anticancer activity of a natural diterpenoid, oridonin, we conducted miRNA expression profiling and statistical analyses that strongly suggested that c-Myc was a… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Fbw7 and Usp28 Regulate Myc Protein Stability in Response to DNA Damage
  • 97
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
  • 740
  • PDF
The ubiquitin-specific protease USP28 is required for MYC stability
  • 337
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
  • 621
  • PDF
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
  • 592
  • PDF
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis
  • 118
  • PDF
...
1
2
3
4
5
...