Triggered liposomal release through a synthetic phosphatidylcholine analogue bearing a photocleavable moiety embedded within the sn-2 acyl chain.

@article{Bayer2014TriggeredLR,
  title={Triggered liposomal release through a synthetic phosphatidylcholine analogue bearing a photocleavable moiety embedded within the sn-2 acyl chain.},
  author={Andrew M Bayer and Shahrina Alam and Samuel I Mattern-Schain and Michael D Best},
  journal={Chemistry},
  year={2014},
  volume={20 12},
  pages={3350-7}
}
Liposomes represent promising carriers for drug delivery applications. To maximize this potential, there has been significant interest in developing liposomal systems encapsulating molecular cargo that are highly stable until their contents are released remotely in a controlled manner. Herein, we describe the design, synthesis, and analysis of a photocleavable analogue of the ubiquitous lipid phosphoatidylcholine (PC) for the development of highly stable and controllable photodisruptable… CONTINUE READING