Trigger-dependent gene expression profiles in cardiac preconditioning: evidence for distinct genetic programs in ischemic and anesthetic preconditioning.

@article{Sergeev2004TriggerdependentGE,
  title={Trigger-dependent gene expression profiles in cardiac preconditioning: evidence for distinct genetic programs in ischemic and anesthetic preconditioning.},
  author={Pavel Sergeev and Rafaela da Silva and Eliana Lucchinetti and Kathrin Zaugg and Thomas Pasch and Marcus C. Schaub and Michael Zaugg},
  journal={Anesthesiology},
  year={2004},
  volume={100 3},
  pages={474-88}
}
BACKGROUND DNA chips facilitate genomic-wide exploration of gene expression. The authors hypothesized that ischemic (IPC) and anesthetic preconditioning (APC) would differentially modulate gene expression in hearts. METHODS Affymetrix rat U34A gene chips were used to explore the transcriptional response to IPC and APC, sustained ischemia (110 min) without reperfusion, and time-matched perfusion in isolated rat hearts. IPC was induced by three cycles of 5 min of ischemia, and APC was induced… CONTINUE READING

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