Trigeminal neuralgia. Current concepts regarding etiology and pathogenesis.

  title={Trigeminal neuralgia. Current concepts regarding etiology and pathogenesis.},
  author={G H Fromm and Christopher F. Terrence and Joseph Charles Maroon},
  journal={Archives of neurology},
  volume={41 11},
There has long been a controversy over the cause of trigeminal neuralgia. Most clinical data favor a peripheral cause. However, most of the experimental data tend to favor a central mechanism. Drugs that are effective in the treatment of trigeminal neuralgia facilitate segmental inhibition in the trigeminal nucleus, as well as depressing excitatory transmission. The most plausible hypothesis to reconcile all of these observations is that trigeminal neuralgia has a peripheral cause and a central… CONTINUE READING

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