Trigeminal nerve injury ErbB3/ErbB2 promotes mechanical hypersensitivity.

@article{Ma2012TrigeminalNI,
  title={Trigeminal nerve injury ErbB3/ErbB2 promotes mechanical hypersensitivity.},
  author={Fei Ma and Liping Zhang and Karin N. Westlund},
  journal={Anesthesiology},
  year={2012},
  volume={117 2},
  pages={
          381-8
        }
}
BACKGROUND Chronic constriction injury of the trigeminal infraorbital nerve results in transient analgesia followed by whisker pad mechanical allodynia in rats. Neuregulin 1 expressed on axonal membranes binds receptor tyrosine kinase ErbB, promoting Schwann cell development and remyelination. This study investigated whether orofacial mechanical allodynia is signaled by ErbB3-ErbB2 heterodimers in injured nerves. METHODS Whisker pad mechanical allodynia (von Frey stimuli) was quantified in… CONTINUE READING

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