Trigeminal and olfactory sensitivity: comparison of modalities and methods of measurement

@article{Comettomuiz1998TrigeminalAO,
  title={Trigeminal and olfactory sensitivity: comparison of modalities and methods of measurement},
  author={J. Enrique Cometto-mu{\~n}iz and William S. Cain},
  journal={International Archives of Occupational and Environmental Health},
  year={1998},
  volume={71},
  pages={105-110}
}
  • J. Cometto-muñiz, W. Cain
  • Published 9 March 1998
  • Psychology
  • International Archives of Occupational and Environmental Health
AbstractObjective: The principal objective was to chart sensitivity for human nasal irritation by alternative psychophysical methods, namely, a common detection procedure versus a nasal lateralization procedure that required the subject to indicate whether a vapor had stimulated the left or right nostril. This objective relates to the broader issues as to (a) whether subjects with normal olfaction (normosmics) can yield, through novel methodology, an index of sensitivity to nasal irritation… 
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Human Trigeminal and Olfactory Chemosensitivity: Detection of Single Chemicals and Binary Mixtures
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Psychometric functions for the olfactory and trigeminal detectability of butyl acetate and toluene
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Psychometric (i.e. concentration–response) functions for the detection of odor, nasal pungency and eye irritation from butyl acetate and toluene suggest that detectability functions provide chemosensory thresholds of closer relevance to environmentally realistic conditions.
Measurement of Nasal Trigeminal Pungency Threshold: :: : Comparison between Normals and Patients with Decreased Sense of Smell*
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The pungency thresholds of hyposmics and anosmics are higher than those of normals, which suggests that a loss or decrease of olfactory sensation is accompanied by a simultaneous decrease of trigeminal chemosensitivity.
Dose-Response Functions for the Olfactory, Nasal Trigeminal, and Ocular Trigeminal Detectability of Airborne Chemicals by Humans.
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A quantitative structure-activity relationship (QSAR) using 5 chemical descriptors, also holds promise to describe, and eventually predict, olfactory and chemesthetic detectability functions, albeit functions from additional compounds are needed to strengthen the QSAR.
Chemesthesis from volatile organic compounds: Psychophysical and neural responses
From chemosensory thresholds to whole body exposures—experimental approaches evaluating chemosensory effects of chemicals
TLDR
Psychophysical approaches that provide information for the evaluation of adverse chemosensory effects at workplaces where volatile chemicals are used are described and a diverse class of chemicals can be described and compared with respect to their chemOSensory potency.
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TLDR
Eye irritation thresholds were remarkably close to nasal pungency thresholds obtained previously in persons lacking olfaction, implying that the eyes could serve as the sites to assess potency for induction of nasal pwnency, an assessment previously limited to testing anosmics.
Sensory Irritation Potency of VOCs Measured Through Nasal Localization Thresholds
Author(s): Cain, William S; Cometto-Muniz, J. Enrique | Abstract: In order to measure "odor unbiased" nasal pungency (e.g., sensory irritation) thresholds, we have resorted in the past to testing
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  • Medicine, Psychology
    Ear, nose, & throat journal
  • 1989
TLDR
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TLDR
Results indicate that irritation intensity and other symptoms are not related in any simple way to odor intensity, which suggests that the symptoms may not be a psychosomatic response to the detection of an aversive odor, and subthreshold levels of VOCs may interact additively or hyperadditively and stimulate trigeminal nerve receptors.
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