Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

@article{Kim2010TrifluoroacetylationOA,
  title={Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine},
  author={J. Kim and Doo Ok Jang},
  journal={Tetrahedron Letters},
  year={2010},
  volume={51},
  pages={683-685}
}
  • J. Kim, Doo Ok Jang
  • Published 2010
  • Chemistry
  • Tetrahedron Letters
  • Abstract We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization. 
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