Trifarotene: First Approval

@article{Scott2019TrifaroteneFA,
  title={Trifarotene: First Approval},
  author={Lesley J. Scott},
  journal={Drugs},
  year={2019},
  volume={79},
  pages={1905 - 1909}
}
  • L. Scott
  • Published 1 November 2019
  • Medicine
  • Drugs
Topical trifarotene (Aklief®) is a first-in-class, fourth-generation retinoid [selective retinoic acid receptor (RAR)-γ agonist] being developed by Galderma Research and Development LLC for the treatment of acne vulgaris. In October 2019 trifarotene received its first global approval in the USA for the topical treatment of acne vulgaris in patients 9 years of age and older. This article summarizes the milestones in the development of trifarotene leading to its first global approval for acne… 
Recent Advances Regarding the Therapeutic Potential of Adapalene
TLDR
Adapalene could be a valuable therapeutic drug into the treatment of several types of cancer and some neurodegenerative diseases could be treated with a suitable formulation for intravenous administration.
Topical Retinoids in Acne Vulgaris: A Systematic Review
TLDR
Topical retinoids are safe and efficacious for the treatment of acne vulgaris and should be used in combination with benzoyl peroxide to optimize results in patients.
Retinoids Delivery Systems in Cancer: Liposomal Fenretinide for Neuroectodermal-Derived Tumors
TLDR
The use and the therapeutic results obtained by using fenretinide-loaded liposomes against neuroectodermal-derived tumors, such as melanoma, in adults, and neuroblastoma, the most common extra-cranial solid tumor of childhood, will be discussed.
Photodegradation of Bexarotene and Its Implication for Cytotoxicity
TLDR
Assessment of bexarotene photostability, including the presence of UV filters, which have been permitted to be used in cosmetic products in Europe and the USA, found non-cancerous murine fibroblasts exhibited marked concentration-dependent inhibition by bexARotene, while the degradation products elicited more pronounced antiproliferative action only at the highest applied concentration.
Phenols in Pharmaceuticals: Analysis of a Recurring Motif.
Phenols and phenolic ethers are significant scaffolds recurring both in nature and among approved small-molecule pharmaceuticals. This compendium presents the first comprehensive compilation and
New drug approvals for 2019: Synthesis and clinical applications.
Clinical study on acupuncture treatment of gastrointestinal damp-heat acne
TLDR
This study is helpful to evaluate the feasibility, preliminary efficacy, and safety of SSGA in the treatment of gastrointestinal damp-heat acne and will be used in sample size calculations for subsequent large-scale studies.
Trifarotene - The latest retinoid.

References

SHOWING 1-10 OF 12 REFERENCES
Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor‐γ agonist trifarotene
First‐ and third‐generation retinoids are the main treatment for acne. Even though efficacious, they lack full selectivity for retinoic acid receptor (RAR) γ, expressed in the epidermis and
Long‐term safety and efficacy of trifarotene 50 μg/g cream, a first‐in‐class RAR‐γ selective topical retinoid, in patients with moderate facial and truncal acne
TLDR
Treatment for both facial and truncal acne has not sufficiently been studied and the current standard of care for facial acne is inadequate.
Topical Retinoids in Acne Vulgaris: A Systematic Review
TLDR
Topical retinoids are safe and efficacious for the treatment of acne vulgaris and should be used in combination with benzoyl peroxide to optimize results in patients.
Retinoids in Acne Management: Review of Current Understanding, Future Considerations, and Focus on Topical Treatments
  • A. Chien
  • Medicine, Biology
    Journal of drugs in dermatology : JDD
  • 2018
TLDR
There is evidence showing its role in improving and preventing one of the most challenging post-acne changes, atrophic acne scarring, and a promising topical retinoid, trifarotene, on the horizon, the acne armamentarium will be further broadened to better manage acne and its related sequelae.
Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment
TLDR
This paper reviews the most important aspects of nonsyndromic ichthyoses, focusing on new knowledge about the pathophysiology of the disorders, which will hopefully lead to novel ideas about therapy.
of Health
  • Lamellar ichthyosis. 2019. http://ghr.nlm.nih.gov/condi tion/lamel lar-ichth yosis #diagn osis. Accessed 15 Oct
  • 2019
Galderma trifarotene development program meets key milestone for lamellar ichthyosis orphan disease [ media release ]
  • 2016
...
...