Triethyltin interferes with Ca2+ signaling and potentiates norepinephrine release in PC12 cells.


We have investigated the effects of triethyltin (TET) on agonist-stimulated Ca2+ signaling and neurosecretion in PC12 cells. Treatment of PC12 cells with 10 microM TET elicited a slow increase of the resting cytosolic free Ca2+ concentration due to Ca2+ release from intracellular stores. Furthermore, TET modified the Ca2+ responses elicited by bradykinin… (More)


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