Triethyl lead toxicity in relation to brain glutathione and glutathione S-transferase.

Abstract

A dose-dependent decrease in the content of reduced glutathione (GSH) was found in the brain of rats following treatment with Pb(Et)3 for varying time intervals. Maximum inhibition of 19% was observed 3 h after the last dose of Pb(Et)3 (8 mg/kg) daily for 3 days. Glutathione S-transferase activity did not change significantly. In vitro, there was no conjugation of GSH with PbEt3 and the addition of brain cytosol did not catalyse the conjugation.

Cite this paper

@article{Chand1982TriethylLT, title={Triethyl lead toxicity in relation to brain glutathione and glutathione S-transferase.}, author={Parmod Chand and J. Clausen}, journal={Toxicology letters}, year={1982}, volume={12 2-3}, pages={181-4} }