Tricyclic drugs reduce proton motive force in Leishmania donovani promastigotes.

  title={Tricyclic drugs reduce proton motive force in Leishmania donovani promastigotes.},
  author={Dan Zilberstein and Varda Liveanu and Amira Gepstein},
  journal={Biochemical pharmacology},
  volume={39 5},
Tricyclic compounds have been suggested as potential anti-leishmanial drugs. We have studied the effect of tricyclic drugs on several cellular functions in L. donovani promastigotes. Imipramine inhibits proline transport and reduces delta pH and cellular ATP at relatively high concentrations (IC50 = 50-80 microM). High concentrations of imipramine are also required to kill L. donovani promastigotes (LD50 greater than 50 microM). The presence of a chlorine atom in the side ring of either… CONTINUE READING


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