Tricyclic antidepressants in the treatment of peptic ulcer disease.

  title={Tricyclic antidepressants in the treatment of peptic ulcer disease.},
  author={Jagdish C. Mangla and Mark Pereira},
  journal={Archives of internal medicine},
  volume={142 2},
Doxepin hydrochloride was given to 12 patients with duodenal ulcer and one patient with an anastomotic ulcer. The dose of doxepin hydrochloride was 100 mg at bedtime, except in patients receiving hemodialysis, where only 50 mg at bedtime was given. Eight patients, including the four receiving hemodialysis, has not responded to treatment after eight weeks of cimetidine and/or antacid therapy. All patients (except one where a minor erosion was left in the duodenum) responded, and healing of the… CONTINUE READING


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