Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents.

@article{Otasowie2014TricyclicAF,
  title={Tricyclic antidepressants for attention deficit hyperactivity disorder (ADHD) in children and adolescents.},
  author={John Otasowie and Xavier Castells and Umonoibalo P Ehimare and Clare Smith},
  journal={The Cochrane database of systematic reviews},
  year={2014},
  volume={9},
  pages={
          CD006997
        }
}
BACKGROUND Attention deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder of childhood onset, which may persist into adulthood. ADHD has a significant impact on a child's daily life, affecting relationships and academic performance. Its core symptoms include developmentally inappropriate levels of inattention, hyperactivity, and impulsive behaviour. Tricyclic antidepressants (TCAs) are sometimes used as second line of treatment in the reduction of ADHD symptoms in… 

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References

SHOWING 1-10 OF 60 REFERENCES
Attention-Deficit/Hyperactivity Disorder: A Selective Overview
The 4-year course of tic disorders in boys with attention-deficit/hyperactivity disorder.
TLDR
It is suggested that comorbidity with a tic disorder has a limited effect on ADHD outcome, and tic disorders had little effect on the psychosocial functioning of subjects with ADHD.
Prevalence of attention-deficit hyperactivity disorders in students. Comparison between DSM-IV and neuropsychological criteria.
TLDR
It is concluded that the use of DSM-IV criteria probably overestimates the prevalence of ADHD, since it detects another behavioral disorders and may be useful as screening, since they have adequate pre-testing performance.
ADHD in a school sample of Brazilian adolescents: a study of prevalence, comorbid conditions, and impairments.
TLDR
The results extend to adolescents well-documented findings in children, indicating that ADHD is quite prevalent in early adolescence and affected youths are at high risk for impairment and dysfunction in multiple domains.
The treatment of attention-deficit hyperactivity disorder in Tourette's syndrome: a double-blind placebo-controlled study with clonidine and desipramine.
TLDR
It is suggested that desipramine may be a useful alternative for the treatment of symptoms of ADHD in children with TS and clonidine showed a statistically significant improvement on a global linear analogue scale, but not on the Hopkins Motor/Vocal Tic Severity scale, the Tourette Syndrome Severity Scale, or the Yale Global Tic Scale.
A controlled study of nortriptyline in children and adolescents with attention deficit hyperactivity disorder.
TLDR
Data suggest that NT is effective in reducing symptoms not only of ADHD but also of oppositionality, and this group of children and adolescents tolerated robust dosing of NT well, with few clinical or cardiovascular adverse events.
Etiologic Subtypes of Attention-Deficit/Hyperactivity Disorder: Brain Imaging, Molecular Genetic and Environmental Factors and the Dopamine Hypothesis
TLDR
Critical issues about etiologic subtypes of ADHD that may involve dopamine are identified, methods that could be used to address these issues are discussed, and old and new theories that may direct research in this area in the future are reviewed.
...
...