Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease.

@article{Paumier2012TricyclicAD,
  title={Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease.},
  author={Katrina L. Paumier and Andrew D. Siderowf and Peggy Auinger and David Oakes and Lalitha Madhavan and Alberto J Espay and Fredy J. Revilla and Timothy J. Collier},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2012},
  volume={27 7},
  pages={880-7}
}
This study examined whether antidepressants delay the need for dopaminergic therapy or change the degree of motor impairment and disability in a population of early Parkinson's disease (PD) patients. Preclinical studies have indicated that antidepressants modulate signaling pathways involved in cell survival and plasticity, suggesting they may serve to both treat PD-associated depression and slow disease progression. A patient-level meta-analysis included 2064 patients from the treatment and… CONTINUE READING

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This study examined whether antidepressants delay the need for dopaminergic therapy or change the degree of motor impairment and disability in a population of early Parkinson 's disease ( PD ) patients .
This study examined whether antidepressants delay the need for dopaminergic therapy or change the degree of motor impairment and disability in a population of early Parkinson 's disease ( PD ) patients .
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