Tricyclic antidepressants and non-Hodgkin lymphoma.


BACKGROUND An increased risk of non-Hodgkin lymphoma (NHL) has been reported among long-term users of tricyclic antidepressants. METHODS The incidence of NHL among 43,932 users of any antidepressant medication (2 or more prescriptions) in the county of North Jutland, Denmark, during 1989-2003 was compared with NHL incidence in all those not using antidepressants (0 or 1 prescription). We used Poisson regression analysis adjusted for age, sex, period, use of immunosuppressive drugs, corticosteroids, or nonsteroidal anti-inflammatory drugs. RESULTS Use of tricyclic antidepressants was associated with an overall increased incidence of NHL (adjusted incidence rate ratio [IRR] = 1.53; 95% confidence interval [CI] = 1.06-2.21) compared with nonuse. The IRR in users with > or =10 prescriptions and 5 or more years of follow-up was 2.50 (CI = 1.43-4.34). Users of other types of antidepressants were not at increased risk of NHL. CONCLUSIONS Our results indicate an increased risk of non-Hodgkin lymphoma specifically among long-term users of tricyclic antidepressant medications.

DOI: 10.1097/EDE.0b013e318176bf98

Cite this paper

@article{Dalton2008TricyclicAA, title={Tricyclic antidepressants and non-Hodgkin lymphoma.}, author={Susanne Oksbjerg Dalton and Aslak Harbo Poulsen and Mette G N\orgaard and Joseph K. Mclaughlin and Christoffer Johansen and S\oren Friis}, journal={Epidemiology}, year={2008}, volume={19 4}, pages={546-9} }