Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin.

@article{Montigny1978TricyclicAL,
  title={Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin.},
  author={Claude de Montigny and George K. Aghajanian},
  journal={Science},
  year={1978},
  volume={202 4374},
  pages={1303-6}
}
Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of… CONTINUE READING