Tricyclic Antidepressant Poisoning
@article{Thanacoody2005TricyclicAP, title={Tricyclic Antidepressant Poisoning}, author={H. K. R. Thanacoody and S. Thomas}, journal={Toxicological Reviews}, year={2005}, volume={24}, pages={205-214} }
Tricyclic antidepressants remain a common cause of fatal drug poisoning as a result of their cardiovascular toxicity manifested by ECG abnormalities, arrhythmias and hypotension. Dosulepin and amitriptyline appear to be particularly toxic in overdose. The principal mechanism of toxicity is cardiac sodium channel blockade, which increases the duration of the cardiac action potential and refractory period and delays atrioventricular conduction. Electrocardiographic changes include prolongation of… CONTINUE READING
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References
SHOWING 1-10 OF 79 REFERENCES
Electrocardiographic and clinical features of tricyclic antidepressant intoxication. A survey of 88 cases and outlines of therapy.
- Medicine
- Annals of clinical research
- 1987
- 14
Serial electrocardiogram changes in acute tricyclic antidepressant overdoses.
- Medicine
- Critical care medicine
- 1997
- 57
Duration of QRS disturbances after severe tricyclic antidepressant intoxication.
- Medicine
- Journal of toxicology. Clinical toxicology
- 1992
- 19
Cardiac arrhythmias and ECG abnormalities in tricyclic antidepressant overdose.
- Medicine
- Clinical toxicology
- 1981
- 40
ECG lead aVR versus QRS interval in predicting seizures and arrhythmias in acute tricyclic antidepressant toxicity.
- Medicine
- Annals of emergency medicine
- 1995
- 121
Brugada Syndrome Mimicked by Tricyclic Antidepressant Overdose
- Medicine
- Journal of cardiovascular electrophysiology
- 2001
- 80
Cardiovascular repercussions of seizures during cyclic antidepressant poisoning.
- Medicine
- Journal of toxicology. Clinical toxicology
- 1995
- 40
Cardiovascular manifestations of tricyclic antidepressant overdose.
- Medicine
- American heart journal
- 1980
- 87
Electrophysiologic effects of imipramine and doxepin on normal and depressed cardiac Purkinje fibers.
- Medicine
- The American journal of cardiology
- 1980
- 39