Tricyclic Antidepressant Poisoning

@article{Thanacoody2005TricyclicAP,
  title={Tricyclic Antidepressant Poisoning},
  author={H. K. R. Thanacoody and S. Thomas},
  journal={Toxicological Reviews},
  year={2005},
  volume={24},
  pages={205-214}
}
  • H. K. R. Thanacoody, S. Thomas
  • Published 2005
  • Medicine
  • Toxicological Reviews
    • Tricyclic antidepressants remain a common cause of fatal drug poisoning as a result of their cardiovascular toxicity manifested by ECG abnormalities, arrhythmias and hypotension. Dosulepin and amitriptyline appear to be particularly toxic in overdose. The principal mechanism of toxicity is cardiac sodium channel blockade, which increases the duration of the cardiac action potential and refractory period and delays atrioventricular conduction. Electrocardiographic changes include prolongation of… CONTINUE READING
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