Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance.

  title={Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance.},
  author={Zhihao Wu and Tomoyo Sawada and Kahori Shiba and Song Liu and Tomoko Kanao and Ryosuke Takahashi and Nobutaka Hattori and Yuzuru Imai and Bingwei Lu},
  journal={Genes & development},
  volume={27 2},
Eukaryotes employ elaborate mitochondrial quality control (MQC) to maintain the function of the power-generating organelle. Parkinson's disease-associated PINK1 and Parkin actively participate in MQC. However, the signaling events involved are largely unknown. Here we show that mechanistic target of rapamycin 2 (mTORC2) and Tricornered (Trc) kinases act downstream from PINK1 to regulate MQC. Trc is phosphorylated in mTORC2-dependent and mTORC2-independent manners and is specifically localized… CONTINUE READING
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