Tricorn protease--the core of a modular proteolytic system.

@article{Tamura1996TricornPC,
  title={Tricorn protease--the core of a modular proteolytic system.},
  author={Tomohiro Tamura and Noriko Tamura and Zdenka Cejka and Reiner Hegerl and Friedrich Lottspeich and Wolfgang Baumeister},
  journal={Science},
  year={1996},
  volume={274 5291},
  pages={
          1385-9
        }
}
Large macromolecular assemblies have evolved as a means of compartmentalizing reactions in organisms lacking membrane-bounded compartments. A tricorn-shaped protease was isolated from the archaeon Thermoplasma and was shown to form a multisubunit proteolytic complex. The 120-kilodalton monomer assembled to form a hexameric toroid that could assemble further into a capsid structure. Tricorn protease appeared to act as the core of a proteolytic system; when it interacted with several smaller… CONTINUE READING
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