Triclosan resistance in Salmonella enterica serovar Typhimurium.

  title={Triclosan resistance in Salmonella enterica serovar Typhimurium.},
  author={Mark Alexander Webber and L P Randall and Susan Cooles and Martin John Woodward and Laura J. V. Piddock},
  journal={The Journal of antimicrobial chemotherapy},
  volume={62 1},
OBJECTIVES The aim of this study was to characterize the mechanisms of resistance to triclosan in Salmonella enterica serovar Typhimurium. METHODS Mutants resistant to triclosan were selected from nine S. enterica serovar Typhimurium strains. Mutants were characterized by genotyping, mutagenesis and complementation of fabI and analysis of efflux activity. Fitness of triclosan-resistant mutants was determined in vitro and in vivo. RESULTS Three distinct resistance phenotypes were observed… CONTINUE READING

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