Triclosan produces statistically significant reduction in plaque, gingivitis and caries but not clinically important benefit

  title={Triclosan produces statistically significant reduction in plaque, gingivitis and caries but not clinically important benefit},
  author={F. Kraglund},
  journal={Evidence-Based Dentistry},
  • F. Kraglund
  • Published 2014
  • Medicine
  • Evidence-Based Dentistry
Data sourcesThe Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and the US National Institutes of Health Trials Register.Study selectionRandomised controlled trials (RCTs) of parallel or crossover design, (with a sufficient wash-out period) of at least six months duration, and irrespective of language or publication status.Data extraction and synthesisStudy assessment and data extraction were carried out independently… Expand
Characterisation of pulpal responses to bacterial challenge and novel sntimicrobials for management of bacterial contamination of infected pulps.
Triclosan’s anti-microbial and anti-inflammatory effect in the treatment of pulpal infection was demonstrated using the SAG model through increased cell viability, reduced area of colonisation and inflammatory marker expression levels form triclosan treatment. Expand
Perturbation and restoration of the fathead minnow gut microbiome after low-level triclosan exposure
The fathead minnow gut microbiome is rapidly and significantly altered by exposure to low, environmentally relevant levels of triclosan, yet largely recovers from this short-term perturbation over an equivalently brief time span, demonstrating both the sensitivity and resilience of the gut flora to challenges by environmental toxicants. Expand
Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL.
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The effectiveness of a toothpaste containing triclosan and polyvinyl-methyl ether maleic acid copolymer in improving plaque control and gingival health: a systematic review.
To compare the effectiveness of triclosan/copolymer and fluoride dentifrices in improving plaque control and gingival health, the Cochrane Controlled Trials Register, MEDLINE and EMBASE was searched. Expand
A meta-analysis of six-month studies of antiplaque and antigingivitis agents.
  • J. Gunsolley
  • Medicine
  • Journal of the American Dental Association
  • 2006
The studies in this systematic review provide strong evidence of the antiplaque, antigingivitis effects of multiple agents and support the use of these agents as part of a typical oral hygiene regimen. Expand
Is there a role for triclosan/copolymer toothpaste in the management of periodontal disease?
The literature pertaining to the efficacy, mode of action and safety of triclosan/copolymer toothpaste has been reviewed and conclusions regarding the efficacy in the home-care management of periodontal disease are presented. Expand
Systematic Review
This study’s findings can provide practical guidelines to steer partnership programs within the academic and clinical bodies, with the aim of providing a collaborative partnership approach to clinical education. Expand
Carranza's Clinical Periodontology
Carranza's clinical periodontology is studied in detail in the context of periodontal disease and its role in human evolution. Expand