Triclosan produces statistically significant reduction in plaque, gingivitis and caries but not clinically important benefit

@article{Kraglund2014TriclosanPS,
  title={Triclosan produces statistically significant reduction in plaque, gingivitis and caries but not clinically important benefit},
  author={F. Kraglund},
  journal={Evidence-Based Dentistry},
  year={2014},
  volume={15},
  pages={6-7}
}
  • F. Kraglund
  • Published 2014
  • Medicine
  • Evidence-Based Dentistry
Data sourcesThe Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase and the US National Institutes of Health Trials Register.Study selectionRandomised controlled trials (RCTs) of parallel or crossover design, (with a sufficient wash-out period) of at least six months duration, and irrespective of language or publication status.Data extraction and synthesisStudy assessment and data extraction were carried out independently… Expand
Characterisation of pulpal responses to bacterial challenge and novel sntimicrobials for management of bacterial contamination of infected pulps.
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Triclosan’s anti-microbial and anti-inflammatory effect in the treatment of pulpal infection was demonstrated using the SAG model through increased cell viability, reduced area of colonisation and inflammatory marker expression levels form triclosan treatment. Expand
Perturbation and restoration of the fathead minnow gut microbiome after low-level triclosan exposure
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The fathead minnow gut microbiome is rapidly and significantly altered by exposure to low, environmentally relevant levels of triclosan, yet largely recovers from this short-term perturbation over an equivalently brief time span, demonstrating both the sensitivity and resilience of the gut flora to challenges by environmental toxicants. Expand
Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL.
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The findings suggest that TCS is not a TH mimic that affects TH-related gene expression, and the impairment of Cyp1a mRNA expression could be due to stimulation by other stressors such as oxidative stress, warranting further investigation into the underlying mechanism in zebrafish. Expand

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