Trichothiodystrophy: sulfur-deficient brittle hair as a marker for a neuroectodermal symptom complex.

@article{Price1980TrichothiodystrophySB,
  title={Trichothiodystrophy: sulfur-deficient brittle hair as a marker for a neuroectodermal symptom complex.},
  author={Vera H. Price and Richard B Odom and Walter H J Ward and Frank T. Jones},
  journal={Archives of dermatology},
  year={1980},
  volume={116 12},
  pages={1375-84}
}
Trichothiodystrophy, or sulfur-deficient brittle hair, is a clinical marker for a neuroectodermal symptom complex that usually features mental and physical retardation and may also include nail dystrophy, lamellar ichthyosis, ocular dysplasia, dental caries, and decreased fertility. Cystine-deficient hair is common to all patients. The hairs from two new patients were studied, and the most distinctive microscopic hair findings were striking bright and dark bands seen with polarizing microscopy… CONTINUE READING