Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK)

@article{Froquet2001TrichotheceneTO,
  title={Trichothecene toxicity on human megakaryocyte progenitors (CFU-MK)},
  author={Romain Froquet and Y. Sibiril and D. Parent-Massin},
  journal={Human and Experimental Toxicology},
  year={2001},
  volume={20},
  pages={84 - 89}
}
Trichothecenes are mycotoxins produced by various species of fungi, which can occur on various agricultural products. Among these compounds, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) are the most naturally encountered and the most potent trichothecenes. Consumption of trichothecene contaminated foods by farm animals and humans leads to mycotoxicosis. Trichothecenes are known to induce haematological disorders such as neutropenia, aplastic anemia and… 
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TLDR
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Trichothecenes in the environment: relevance to human health.
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TLDR
It was concluded that simple trichothecenes possessing strong phytotoxicity and minimal mammalian toxicity in vitro can be identified.
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TLDR
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TLDR
Screening of potential myelotoxicity of the emerging mycotoxins Beauvericin, Enniatin b and Moniliformin using human hematopoietic progenitor clonogenic assays found variation of distribution of CFU-MK colonies according to their size has been observed, and in vitro effects may be responsible for in-vivo hematological troubles in case of consumption of contaminated commodities.
Toxicological mechanisms and potential health effects of deoxynivalenol and nivalenol.
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Human myelotoxicity of two phycotoxins, okadaic acid and domoic acid. An in vitro study
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