Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.

@article{Hosoya2012TrichostatinAJ,
  title={Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.},
  author={T. Hosoya and T. Hirokawa and M. Takagi and K. Shin-ya},
  journal={Journal of natural products},
  year={2012},
  volume={75 2},
  pages={
          285-9
        }
}
Three new trichostatin analogues, JBIR-109 (1), JBIR-110 (2), and JBIR-111 (3), were isolated from the culture of the marine sponge-derived Streptomyces sp. strain RM72, together with trichostatin A (4) and trichostatic acid (5). The planar structures of 1-3 were determined on the basis of extensive NMR and MS analyses. In addition, the absolute configurations of the amino acid residues were determined by Marfey's method. The histone deacetylase inhibitory activities of 1-5 were examined, and… Expand
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References

SHOWING 1-9 OF 9 REFERENCES
JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634
A new antifungal antibiotic, trichostatin.
[Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A].
  • M. Yoshida
  • Biology, Medicine
  • Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
  • 2007
Novel bile acids from bear bile powder and bile of geese.
EzTaxon: a web-based tool for the identification of prokaryotes based on 16S ribosomal RNA gene sequences.