Trichostatin a inhibits corneal haze in vitro and in vivo.

@article{Sharma2009TrichostatinAI,
  title={Trichostatin a inhibits corneal haze in vitro and in vivo.},
  author={Ajay Sharma and Maneesh M Mehan and Sunilima Sinh{\'a} and John W. Cowden and Rajiv R Mohan},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 6},
  pages={2695-701}
}
PURPOSE Trichostatin A (TSA), a histone deacetylase inhibitor, has been shown to suppress TGF-beta-induced fibrogenesis in many nonocular tissues. The authors evaluated TSA cytotoxicity and its antifibrogenic activity on TGF-beta-driven fibrosis in the cornea with the use of in vitro and in vivo models. METHODS Human corneal fibroblasts (HSFs) were used for in vitro studies, and New Zealand White rabbits were used for in vivo studies. Haze in the rabbit cornea was produced with… CONTINUE READING

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Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
CorneaIs associated anatomic site ofCorneal Diseases
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Two - minute topical treatment of TSA on rabbit corneas subjected to -9 D PRK significantly decreased corneal haze in vivo .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
Haze in the rabbit cornea was produced with photorefractive keratectomy ( PRK ) using excimer laser .
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