Trichostatin A regulates peroxiredoxin expression and virulence of the parasite Entamoeba histolytica.


Histone deacetylation is associated with a repressed chromatin state, and histone acetylase and deacetylase activities have been previously described in Entamoeba histolytica. To investigate their roles in the control of Entamoeba gene expression, the parasite was grown in 50 nM trichostatin A (TSA), an inhibitor of histone deacetylase. TSA enhanced the… (More)
DOI: 10.1016/j.molbiopara.2007.11.014


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