Trichostatin A-mediated upregulation of p21WAF1 contributes to osteoclast apoptosis

@article{Yi2007TrichostatinAU,
  title={Trichostatin A-mediated upregulation of p21WAF1 contributes to osteoclast apoptosis},
  author={Tacghee Yi and Jeong-Hwa Baek and Hye-Jin Kim and Mi-Hye Choi and Sang-Beom Seo and Hyun-Mo Ryoo and Gwan-Shik Kim and Kyung Mi Woo},
  journal={Experimental & Molecular Medicine},
  year={2007},
  volume={39},
  pages={213-221}
}
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about the effect of HDIs on mature osteoclasts, which may have significance for their therapeutic use. Here, we demonstrate a novel action of HDIs on osteoclast apoptosis. Primary multinucleated mature osteoclasts were prepared from mouse bone marrow cells. Treatment of osteoclasts with… CONTINUE READING

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