Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice.

@article{Choi2005TrichostatinAE,
  title={Trichostatin A exacerbates atherosclerosis in low density lipoprotein receptor-deficient mice.},
  author={Jae-Hoon Choi and Ki-Hoan Nam and Jiyun Kim and Min Won Baek and J S Park and Harriet Park and Ho Jeong Kwon and O Kwon and Dae-Yong Kim and Goo Taeg Oh},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 11},
  pages={2404-9}
}
OBJECTIVE Histone acetylation has been shown to be involved in expression of a restricted set of cellular genes including various proinflammatory molecules. We aimed to investigate the relationship between histone acetylation and atherosclerosis. METHODS AND RESULTS In low-density lipoprotein (LDL) receptor-deficient (Ldlr(-/-)) mice fed an atherogenic diet for 4 or 8 weeks, trichostatin A (TSA), a specific histone deacetylase inhibitor, exacerbated atherosclerosis without alteration on… CONTINUE READING

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