Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation

@article{Piacentini2006TrichostatinAE,
  title={Trichostatin A enhances the response of chemotherapeutic agents in inhibiting pancreatic cancer cell proliferation},
  author={Paolo Piacentini and Massimo Donadelli and Chiara Costanzo and Patrick S Moore and Marta Palmieri and Aldo Scarpa},
  journal={Virchows Archiv},
  year={2006},
  volume={448},
  pages={797-804}
}
Pancreatic cancer is an aggressive neoplasia, and standard chemotherapies are by and large ineffective. The purpose of this work was to get a comprehensive preclinical study on the ability of anticancer drug combinations that best inhibit growth of pancreatic adenocarcinoma cells. We evaluated the in vitro growth inhibition of ten pancreatic cancer cell lines to gemcitabine and 5-fluorouracil, newer generation cytotoxic agents (oxaliplatin, irinotecan), targeted therapy (gefitinib) and a… CONTINUE READING

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