Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering.

@article{Lim2013TrichostatinAE,
  title={Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering.},
  author={Shiang Yong Lim and Priyadharshini Sivakumaran and Duncan Edward Crombie and Gregory James Dusting and Alice P{\'e}bay and Rodney James Dilley},
  journal={Stem cells translational medicine},
  year={2013},
  volume={2 9},
  pages={
          715-25
        }
}
Human induced pluripotent stem (iPS) cells are a promising source of autologous cardiomyocytes to repair and regenerate myocardium for treatment of heart disease. In this study, we have identified a novel strategy to enhance cardiac differentiation of human iPS cells by treating embryoid bodies (EBs) with a histone deacetylase inhibitor, trichostatin A (TSA), together with activin A and bone morphogenetic protein 4 (BMP4). Over a narrow window of concentrations, TSA (1 ng/ml) directed the… CONTINUE READING
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