Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.

@article{Xiong2012TrichostatinAA,
  title={Trichostatin A, a histone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells.},
  author={H. W. Xiong and Wan Tong Du and Yan-jie Zhang and J. Z. Hong and Wen-Yu Su and Jie-ting Tang and Ying-chao Wang and Rong Lu and Jingyuan Fang},
  journal={Molecular carcinogenesis},
  year={2012},
  volume={51 2},
  pages={174-84}
}
Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2-containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulators of JAK/STAT signaling, have been reported to have tumor suppressor functions. However, in colorectal cancer (CRC) cells, the mechanisms that regulate SOCS and SHP1 genes, and the cause of abnormalities in the… CONTINUE READING