Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts.

@article{Rombouts2002TrichostatinAA,
  title={Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts.},
  author={Krista Rombouts and T. Niki and Patricia Greenwel and Alain Vandermonde and Annemie Wielant and Karine H. Hellemans and Pieter De Bleser and Minoru Yoshida and Detlef B Schuppan and Marcos Rojkind and A. A. J. Geerts},
  journal={Experimental cell research},
  year={2002},
  volume={278 2},
  pages={184-97}
}
Excessive production of collagens by alpha-smooth muscle actin (alpha-SMA)-positive myofibroblasts leads to fibrotic skin diseases, such as hypertrophic scarring. This process is characterized by an imbalance between extracellular matrix (ECM) synthesis and degradation, while transforming growth factor beta (TGF-beta(1)), known to be a key mediator of fibrogenesis, is up-regulated. In this study we have investigated the possible antifibrogenic effect of Trichostatin A (TSA), a histone… CONTINUE READING