Trichosporon beigelii, an emerging pathogen resistant to amphotericin B.

  title={Trichosporon beigelii, an emerging pathogen resistant to amphotericin B.},
  author={Thomas J Walsh and G. Melcher and Michael G. Rinaldi and J A Lecciones and Deanna A. McGough and Paul Richard Kelly and Jeongwu Lee and David R Callender and Moshe Rubin and Philip A. Pizzo},
  journal={Journal of clinical microbiology},
  volume={28 7},
Trichosporon beigelii caused fatal disseminated infections that were resistant to amphotericin B in two granulocytopenic patients. In vitro susceptibility studies demonstrated that both index strains of T. beigelii were inhibited but not killed by amphotericin B at achievable concentrations in serum. The minimum lethal concentration for both isolates was greater than or equal to 18 micrograms/ml. Five of seven other isolates were found to have a similar pattern of amphotericin B resistance. The… CONTINUE READING

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